NKG2D ligand 4 (NKG2D ligand 4, NKG2DL4, N2DL-4, retinoic acid early transcript 1E, lymphocyte effector toxicity activation ligand, RAE-1-like transcript 4, RL-4, RAET1E, LETAL, N2DL4, ULBP4, UNQ1867/PRO4303)

Function: - ligand for the NKG2D receptor - delivers activating signals to NK cells & promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes - binds to KLRK1/NKG2D - does not interacts with the CMV glycoprotein UL16 Structure: - belongs to the MHC class I family Compartment: membrane Alternative splicing: named isoforms=3 Expression: - predominantly expressed in skin - also expressed in testis & trachea Pathology: - up-regulated in tumor cells of different origins - expression progressively decreased after treatment of tumor cells with retinoic acid

General

glycoprotein membrane protein

Properties

SIZE: MW = 30 kD entity length = 263 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-30} MHC class I alpha-1 like {31-116} MOTIF: N-glycosylation site {N36} MHC class I alpha-2 like {117-207} MOTIF: cysteine residue {C126} MODIFICATION: cysteine residue {C189} N-glycosylation site {N154} cysteine residue {C189} MODIFICATION: cysteine residue {C126} N-glycosylation site {N212} serine-rich region {219-222} MOTIF: serine residue (SEVERAL) transmembrane domain {226-248}

Database Correlations

UniProt Q8TD07 Pfam PF00129

References

UniProt :accession Q8TD07