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CD159c; NKG2-C type II integral membrane protein; NKG2-C-activating NK receptor; NK cell receptor C; CD159 antigen-like family member C (KLRC2, NKG2C)
Function:
- plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells & some cytotoxic T-cells
- can form disulfide-bonded heterodimer with CD94
Structure: contains 1 C-type lectin domain
Compartment: membrane
Expression: natural killer cells
Polymorphism: two alleles are known
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
killer cell lectin-like receptor C subfamily or NKG2 receptor
Properties
SIZE: entity length = 231 aa
MW = 26 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {71-93}
N-glycosylation site {N100}
C-type lectin {116-229}
MOTIF: cysteine residue {C117}
MODIFICATION: cysteine residue {C128}
cysteine residue {C128}
MODIFICATION: cysteine residue {C117}
cysteine residue {C145}
MODIFICATION: cysteine residue {C227}
N-glycosylation site {N149}
N-glycosylation site {N178}
cysteine residue {C206}
MODIFICATION: cysteine residue {C219}
cysteine residue {C219}
MODIFICATION: cysteine residue {C206}
cysteine residue {C227}
MODIFICATION: cysteine residue {C145}
Database Correlations
OMIM 602891
UniProt P26717
Pfam PF00059
Entrez Gene 3822
Kegg hsa:3822
References
UniProt :accession P26717