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CD159a; NKG2-A/NKG2-B type II integral membrane protein; NKG2-A/B-activating NK receptor; NK cell receptor A; CD159 antigen-like family member A; killer cell lectin-lik receptor subfamily C member 1 (KLRC1, NKG2A)
Function:
- plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells & some cytotoxic T-cells
- can form disulfide-bonded heterodimer with CD94
Structure: contains 1 C-type lectin domain
Compartment: membrane
Alternative splicing: named isoforms=2; A,B
Expression: natural killer cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
killer cell lectin-like receptor C subfamily or NKG2 receptor
Properties
SIZE: entity length = 233 aa
MW = 26 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {71-93}
N-glycosylation site {N102}
N-glycosylation site {N103}
C-type lectin {118-231}
MOTIF: cysteine residue {C119}
MODIFICATION: cysteine residue {C130}
cysteine residue {C130}
MODIFICATION: cysteine residue {C119}
cysteine residue {C147}
MODIFICATION: cysteine residue {C229}
N-glycosylation site {N151}
N-glycosylation site {N180}
cysteine residue {C208}
MODIFICATION: cysteine residue {C221}
cysteine residue {C221}
MODIFICATION: cysteine residue {C208}
cysteine residue {C229}
MODIFICATION: cysteine residue {C147}
Database Correlations
OMIM 161555
UniProt P26715
Pfam PF00059
Entrez Gene
Kegg hsa:3821
References
- UniProt :accession P26715
- Functional Glycomics gateway - Glycan binding; Note: NKG-2A
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_245