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nitrous oxide; laughing gas (N2O)
Non-flammable, nearly odorless gas.
Pharmacokinetics:
1) rapidly eliminated by pulmonary diffusion
2) no evidence of biotransformation
Adverse effects:
- chronic abuse may lead to functional vitamin B12 deficiency due to inactivation [3]
- peripheral neuropathy from functional vitamin B12 deficiency & subacute combined degeneration of the spinal cord [4]
Laboratory:
1) nitrous oxide in blood
a) specimen: whole blood
b) methods: GLC, GC-MS
2) other labs with Loincs
- nitrous oxide in serum/plasma
- nitrous oxide delivered.total volume
Mechanism of action: good anesthetic at safe concentrations
Related
nitric oxide (NO, endothelium derived relaxation factor {EDRF})
General
analgesic (antalgic)
Properties
MISC-INFO: elimination route LUNG
therapeutic-range 17-22 ML/DL
pregnancy-category -
safety in lactation ?
Database Correlations
PUBCHEM cid=948
References
- Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz
ed, WB Saunders, Philadelphia, 1995
- Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed,
WB Saunders, Philadelpha 1995
- Medical Knowledge Self Assessment Program (MKSAP) 18,
American College of Physicians, Philadelphia 2018
- Kneisel K
Neuropathy After Recreational Use of Laughing Gas.
Clinicians should be aware of adverse effects of this increasingly popular drug.
MedPage Today August 23, 2021
https://www.medpagetoday.com/casestudies/neurology/94170
- Pedersen OB, Hvas AM, Grove EL
A 19-year-old man with a history of recreational inhalation of nitrous oxide
with severe peripheral neuropathy and central pulmonary embolism.
Am J Case Rep 2021. Aug 11;22:e931936
PMID: 34376630
https://www.amjcaserep.com/abstract/index/idArt/931936
Component-of
co2/nitrous oxide