nitrogen mustard/vincristine (Oncovin)/prednisone/ procarbazine (MOPP)

Indications: - chemotherapy regimen for treatment of Hodgkin's disease; associated with 84% complete remission & 48% 14 year survival Adverse effects: 1) nausea & vomiting 2) bone marrow suppression 3) sterility a) 90% of males completing 6 cycles of therapy b) younger women are more resilient than older women 4) 2% risk of developing secondary acute leukemia within 10 years of therapy (acute non-lymphocytic leukemia)

References

- Medical Knowledge Self Assessment Program (MKSAP) 11, 14, American College of Physicians, Philadelphia 1998, 2006

Components

mechlorethamine; nitrogen mustard (Mustargen, Nor-mustard, Chlorethazine) prednisone (Deltasone, Orasone, Liquid Pred, Meticortin, Rayos) procarbazine (Matulane, Natulan, ibenzmethyzin) vincristine; 22-oxovincaleukoblastine; leurocristine (Oncovin, Vincasar PFS)