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nitrilase homolog 2 (NIT2)
Function:
- overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle
Structure:
- belongs to the UPF0012 family
- contains 1 CN hydrolase domain
Compartment: cytoplasm
Expression:
- detected in fetal brain (at protein level)
- ubiquitous
- detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine & colon Mass spectroscopy: mass=30585; Method=maldi [2]
General
enzyme
phosphoprotein
Properties
SIZE: entity length = 276 aa
MW = 31 kD
COMPARTMENT: cytoplasm
MOTIF: CN hydrolase {4-270}
MOTIF: glutamate residue {E43}
lysine residue {K112}
Tyr phosphorylation site {Y145}
cysteine residue {C153}
Ser phosphorylation site {S266}
Tyr phosphorylation site {Y269}
Database Correlations
UniProt Q9NQR4
Pfam PF00795
Kegg hsa:5695
References
- UniProt :accession Q9NQR4
- Lin CH, Chung MY, Chen WB, Chien CH.
Growth inhibitory effect of the human NIT2 gene and its
allelic imbalance in cancers.
FEBS J. 2007 Jun;274(11):2946-56. Epub 2007 May 4.
PMID: 17488281