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nim1 kinase

Phosphorylates & inhibits c-wee1 kinase. Higher eukaryotic homologs of nim1 have not been identified

Interactions

molecular events

General

fungus-specific molecule serine/threonine kinase tyrosine kinase (protein tyrosine kinase, PTK)

Properties

SIZE: MW = 70-80 kD STATE: active state MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site Tyr phosphorylation site

References

  1. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 1991 Oct 4;67(1):197-211. PMID: 1913817
  2. Parker LL, Walter SA, Young PG, Piwnica-Worms H. Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase. Nature. 1993 Jun 24;363(6431):736-8. PMID: 8515817
  3. Wu L, Russell P. Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase. Nature. 1993 Jun 24;363(6431):738-41. PMID: 8515818
  4. Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: 7877684