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NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
5-armed multicenter NIH-funded study ,
1583 patients > 40 years of age, 64% female
all patients with knee pain > 6 months duration & radiographic evidence of osteoarthritis ,
Glucosamine 500 mg TID
Chondroitin sulfate 400 mg TID
Glucosamine plus Chondroitin sulfate
Celebrex 200 mg QD
Placebo ,
Acetaminophen, up to 4 g/day, for additional pain relief ,
Patients evaluated at baseline, 4,8,16 & 24 weeks
Primary outcome measure: 20% improvement from baseline (WOMAC pain severity scale) ,
Results:
1) Celebrex better than placebo
2) Glucosamine, chondroitin sulfate, or combination no better than placebo for mild pain
3) Combination of glucosamine + chondroitin sulfate better than placebo for moderate-severe pain
Related
chondroitin sulfate
glucosamine (Cosamin, Osteo-Bi-Flex)
osteoarthritis (OA)
General
clinical trial
References
- Prescriber's Letter 12(12): 2005
Glucosamine, Chondrotin and Selenium: Recent Osteoarthritis
Research
Detail-Document#: 211215
(subscription needed) http://www.prescribersletter.com
- Questions and Answers: NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
http://nccam.nih.gov/news/19972000/121100/qa.htm
- Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM,
Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE,
Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F,
Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD,
Shi H, Brandt KD, Moskowitz RW, Williams HJ.
Glucosamine, chondroitin sulfate, and the two in combination
for painful knee osteoarthritis.
N Engl J Med. 2006 Feb 23;354(8):795-808.
PMID: 16495392
- Hochberg MC.
Nutritional supplements for knee osteoarthritis--still no
resolution.
N Engl J Med. 2006 Feb 23;354(8):858-60. No abstract available.
PMID: 16495399