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nicotinic acid receptor 1; G-protein coupled receptor 109A; G-protein coupled receptor HM74A (GPR109A, HCAR2, HM74A)
Function:
1) high affinity receptor for nicotinic acid
2) mediates its anti-lipolytic effect through a Gi protein- mediated inhibition of adenylyl cyclase
3) pharmacological effect requires nicotinic acid doses much higher than those provided by a normal diet
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: membrane
Expression: largely restricted to adipose tissue & spleen
General
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 42 kD
entity length = 363 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-33}
transmembrane domain {34-54}
cytoplasmic loop {55-63}
transmembrane domain {64-84}
exoplasmic loop {85-102}
MOTIF: cysteine residue {C100}
MODIFICATION: cysteine residue {C177}
transmembrane domain {103-123}
cytoplasmic loop {124-142}
transmembrane domain {143-163}
exoplasmic loop {164-192}
MOTIF: cysteine residue {C177}
MODIFICATION: cysteine residue {C100}
transmembrane domain {193-213}
cytoplasmic loop {214-229}
transmembrane domain {230-250}
exoplasmic loop {251-273}
transmembrane domain {274-294}
cytoplasmic domain {295-363}
Database Correlations
UniProt Q8TDS4
Pfam PF00001
Kegg hsa:3384
References
- UniProt :accession Q8TDS4
- SeattleSNPs
http://pga.gs.washington.edu/data/gpr109a/