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nicotinic acid/simvastatin (Simcor)
Indications:
1) hypercholesterolemia
2) not for initial therapy
3) reserve for patients who don't reach their goals with either agent alone
Dosage: 1-2 tablets/day, maximum 2 tablets/day
Tablets:
- 20 mg of simvastatin
- 3 niacin strengths: 500 mg, 750 mg, & 1000 mg
Adverse effects:
- flushing (59%), headache (4.5%), itching (3.2%), nausea (3.2%)
- also see simvastatin & niacin
Interactions
drug interactions
General
pharmacologic combination
References
- Prescriber's Letter 15(4): 2008
New Formulation Simcor and the Investigational Drug Cordaptive
Detail-Document#: 240411
(subscription needed) http://www.prescribersletter.com
Components
nicotinic acid (niacin, vitamin B3, Niaspan)
simvastatin (Zocor)