Nicalin (nicastrin-like protein, NCLN)

Function: - may antagonize Nodal signaling & subsequent organization of axial structures during mesodermal patterning - interacts with NOMO₂ - due to the strong similarity between NOMO1, NOMO₂ & NOMO3, it probably also interacts with NOMO1 & NOMO3 - participates in a large protein complex, which is not related to the gamma-secretase complex Structure: belongs to the nicastrin family Compartment: endoplasmic reticulum membrane Alternative splicing: named isoforms=2 Expression: - highly expressed in pancreas & skeletal muscle &, at lower levels, in heart

General

glycoprotein membrane protein

Properties

SIZE: MW = 63 kD entity length = 563 aa COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-42} N-glycosylation site {N241} N-glycosylation site {N428} transmembrane domain {523-543}

Database Correlations

UniProt Q969V3 Pfam PF05450

References

UniProt :accession Q969V3