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protein Niban; cell growth-inhibiting gene 39 protein; protein FAM129A (FAM129A, C1orf24, NIBAN, GIG39)
Function:
- regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 & RPS6KB1
- may be involved in the endoplasmic reticulum stress response (putative)
Structure:
- belongs to the Niban family
Compartment: cytoplasm
Expression:
- strongly expressed in heart, skeletal muscle, pancreas, white blood cells & prostate
- lesser expression in colon & spleen
- not expressed in normal thyroid tissue or normal kidney
Pathology:
- expressed in renal carcinoma cells
- expressed thyroid tumors
a) papillary thyroid carcinoma
b) oxyphilic thyroid tumors
Related
renal cell carcinoma (hypernephroma, Grawitz tumor)
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 928 aa
MW = 103 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S579}
Ser phosphorylation site {S581}
Ser phosphorylation site {S582}
Ser phosphorylation site {S592}
Ser phosphorylation site {S596}
Ser phosphorylation site {S602}
Ser phosphorylation site {S646}
glutamate-rich region {683-864}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S926}
Database Correlations
UniProt Q9BZQ8
Entrez Gene 116496
Kegg hsa:116496
References
UniProt :accession Q9BZQ8