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NGFI-A-binding protein 2; EGR-1-binding protein 2; melanoma-associated delayed early response protein; MADER protein (NAB2, MADER)
Function:
1) transcriptional repressor for EGR1, EGR2
2) isoform 2 lacks transcriptional repressor activity
3) homomultimers may associate with EGR1 bound to DNA
Compartment:
- nucleus
- isoform 2 is not localized to the nucleus
Alternative splicing: named isoforms=3
Expression:
- widely expressed at low levels
- highly expressed in melanoma cell lines
General
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 57 kD
entity length = 525 aa
COMPARTMENT: cell nucleus
MOTIF: NCD1. {35-113}
NCD2. {267-356}
nuclear translocation signal {353-384}
Database Correlations
OMIM 602381
UniProt Q15742
PFAM correlations
References
UniProt :accession Q15742