NF-kappa-B inhibitor-like protein 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; I-kappa-B-related protein; IkappaBR (NFKBIL2, IKBR, TONSL)

Function: - role in the regulation of NF-kappa-B transcription factor complexes - acts either as a negative or positive regulator of NF-kappa-B mediated activation of transcription Structure: - contains 3 ANK repeats - contains 7 LRR repeats (leucine-rich repeats) - contains 8 TPR repeats Compartment: cytoplasm Alternative splicing: named isoforms=2 Expression: - expressed in heart, skeletal muscle & tracheal epithelial cells

Properties

SIZE: entity length = 1378 aa MW = 151 kD COMPARTMENT: cytoplasm MOTIF: tetratricopeptide repeat {27-60} tetratricopeptide repeat {67-100} tetratricopeptide repeat {107-147} tetratricopeptide repeat {162-195} tetratricopeptide repeat {202-235} tetratricopeptide repeat {242-275} tetratricopeptide repeat {311-344} tetratricopeptide repeat {352-385} glutamate-rich region {448-509} MOTIF: glutamate residue (SEVERAL) ankyrin repeat NAME: ankyrin repeat SITE: 528-557 ankyrin repeat NAME: ankyrin repeat SITE: 561-590 ankyrin repeat NAME: ankyrin repeat SITE: 597-626 leucine-rich repeat SITE: 1069-1093 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1097-1122 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1128-1151 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1188-1212 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1247-1270 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1275-1300 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1331-1354 MOTIF: leucine residue (SEVERAL)

Database Correlations

OMIM 604546 UniProt Q96HA7 PFAM correlations

References

UniProt :accession Q96HA7