Contents

Search

erythroid-restricted nuclear factor E2

Function: - transcription factor that recognizes the extended AP1-site [(C/T)TGCTCA(C/G)TCA(T/C)] found in the upstream locus control regions of the alpha-globin gene cluster & beta-globin gene cluster - NF-E2 links intestinal transport of iron to erythropoiesis [3]

General

basic leucine zipper (bZIP) family protein molecular complex

Properties

COMPARTMENT: cell nucleus CELL: erythroid progenitor cell MOTIF: bZIP domain MOTIF: basic DNA-binding motif leucine zipper FOR-BINDING-VIA: leucine zipper FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: leucine zipper SUBUNITS: nuclear factor E2 45 kD subunit MOTIF: proline residue {59-62} (4) proline residue {77-82} (6) bZIP domain MOTIF: basic DNA-binding motif leucine zipper FOR-BINDING-VIA: leucine zipper FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: leucine zipper DNA-binding motif SITE: 268-287 leucine zipper SITE: 294-339 FOR-BINDING-VIA: leucine zipper transcription factor MafK MOTIF: DNA-binding motif SITE: 51-76 bZIP domain MOTIF: basic DNA-binding motif leucine zipper FOR-BINDING-VIA: leucine zipper FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: leucine zipper leucine zipper SITE: 86-114 FOR-BINDING-VIA: leucine zipper

References

  1. Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Erythroid transcription factor NF-E2 is a haematopoietic- specific basic-leucine zipper protein. Nature. 1993 Apr 22;362(6422):722-8. PMID: 8469283
  2. Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488-92. PMID: 8265578
  3. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996 pg 1317-1325

Components

transcription factor MafK; erythroid transcription factor NF-E2 p18 subunit (MAFK) transcription factor NF-E2 45 kD subunit; nuclear factor erythroid-derived 2 45 kD subunit; p45 NF-E2; leucine zipper protein NF-E2 (NFE2)