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NFAT activation molecule 1; calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1 (NFAM1, CNAIP)
Function:
- may function in immune system as a receptor that activates downstream cytokine genes via the calcineurin/NFAT-signaling pathway
- activates transcription of IL-13 & TNF-alpha genes
- may be involved in regulation of B-cell, but not T-cell, development
- overexpression activates downstream effectors without ligand binding or antibody cross-linking
- interacts with ZAP70 & SYK
- no direct interaction with the B-cell antigen receptor (BCR) (putative)
Structure:
- N-glycosylated
- the ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions
- the phosphorylated ITAM domain binds ZAP70 & SYK
- contains 1 Ig-like V-type domain
- contains 1 ITAM domain
Compartment:
- cell membrane; single-pass type 1 membrane protein (putative)
- partially recruited to lipid rafts upon BCR stimulation (putative)
Expression:
- highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines & lymphocytes
- also expressed in spleen B & T cells, & lung
- expressed at low level in non-immune tissue
Related
calcineurin; serine/threonine protein phosphatase 3 (formerly PP2B)
immunoreceptor tyrosine-based activator motif (ITAM)
nuclear factor of activated T-cells (NFATC transcription complex, NFAT)
General
glycoprotein
membrane protein
phosphoprotein
Properties
SIZE: entity length = 270 aa
MW = 30 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-42}
immunoglobulin superfamily domain {50-150}
MOTIF: cysteine residue {C65}
MODIFICATION: cysteine residue {C114}
N-glycosylation site {N107}
cysteine residue {C114}
MODIFICATION: cysteine residue {C65}
transmembrane domain {164-184}
ITAM {209-237}
MOTIF: Tyr phosphorylation site {Y220}
Tyr phosphorylation site {Y231}
Tyr phosphorylation site {Y267}
Database Correlations
OMIM 608740
UniProt Q8NET5
Entrez Gene 150372
Kegg hsa:150372
References
UniProt :accession Q8NET5