Nexilin (F-actin binding protein, Nelin, NEXN)

Function: - role in regulating cell migration through association with the actin cytoskeleton - interacts with F-actin Structure: contains 1 Ig-like (immunoglobulin-like) domain Compartment: - cytoplasm, cytoskeleton, cell junction, adherens junction (putative) - localizes to the cell-matrix AJ - not found at the cell-cell AJ (putative) Alternative splicing: named isoforms=3 Expression: - abundantly expressed in heart & skeletal muscle, & at lower levels in placenta, lung, liver & pancreas - also expressed in HeLa S3 & Molt-4 cells

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 675 aa MW = 81 kD COMPARTMENT: cytoplasm MOTIF: glutamate-rich region {43-575} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S80} Ser phosphorylation site {S365} Thr phosphorylation site {T370} Ser phosphorylation site {S569} immunoglobulin superfamily domain {582-670}

Database Correlations

UniProt Q0ZGT2 Pfam PF07679

References

UniProt :accession Q0ZGT2