Search
neurotrophin-4; NT-4; neurotrophin-5; NT-5; neutrophic factor 4 (NTF4, NTF5)
Function:
- target-derived survival factor for peripheral sensory sympathetic neurons
Structure: belongs to the NGF-beta family
Compartment: secreted
Expression:
- highest levels in prostate, lower levels in thymus, placenta, & skeletal muscle
- expressed in embryonic & adult tissues
Pathology:
- defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O
Interactions
molecular events
General
glycoprotein
neurotrophic factor or neurotrophin
Properties
SIZE: entity length = 210 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
N-glycosylation site {N76}
cysteine residue {C97}
MODIFICATION: cysteine residue {C170}
cysteine residue {C141}
MODIFICATION: cysteine residue {C199}
cysteine residue {C158}
MODIFICATION: cysteine residue {C201}
cysteine residue {C170}
MODIFICATION: cysteine residue {C97}
cysteine residue {C199}
MODIFICATION: cysteine residue {C141}
cysteine residue {C201}
MODIFICATION: cysteine residue {C158}
Database Correlations
OMIM correlations
MORBIDMAP 162662
UniProt P34130
Pfam PF00243
Entrez Gene 4909
Kegg hsa:4909
References
- UniProt :accession P34130
- Hallbook F et al.
Evolutionary studies of the nerve growth factor family reveal
a novel member abundantly expressed in Xenopus ovary.
Neuron 6:845-858 1991
PMID: 2025430
- Berkemeier LR et al.
Neurotrophin-5: a novel neurotrophic factor that activates trk
and trkB.
Neuron 7:857-66 1991
PMID: 1742028