Search
neurotrophin-3; NT-3; HDNF; nerve growth factor 2; NGF-2; neurotrophic factor 3 (NTF3)
Function:
- neurotrophic for sensory neurons of nodose ganglion
- binds to gp145trkC, gp145trkB, gp140trk
- seems to promotes the survival of visceral & proprioceptive sensory neurons
- role in neuroplasticity, learning & memory [3]
Structure: belongs to the NGF-beta family
Compartment: secreted
Expression:
- brain & peripheral tissues
- upregulated by fasting via switch from brain utilization of glucose to lactate [3]
- high-intensity exercise induces an increase in serum BDNF [3]
Polymorphism:
- variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia
- this seems not to be the case
Interactions
molecular events
General
glycoprotein
neurotrophic factor or neurotrophin
Properties
SIZE: entity length = 257 aa
MW = 29 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
N-glycosylation site {N131}
cysteine residue {C152}
MODIFICATION: cysteine residue {C217}
cysteine residue {C195}
MODIFICATION: cysteine residue {C246}
cysteine residue {C205}
MODIFICATION: cysteine residue {C248}
cysteine residue {C217}
MODIFICATION: cysteine residue {C152}
cysteine residue {C246}
MODIFICATION: cysteine residue {C195}
cysteine residue {C248}
MODIFICATION: cysteine residue {C205}
Database Correlations
OMIM 162660
UniProt P20783
Pfam PF00243
Entrez Gene 4908
Kegg hsa:4908
References
- UniProt :accession P20783
- Hohn A, Leibrock J, Bailey K, Barde YA.
Identification and characterization of a novel member of the
nerve growth factor/brain-derived neurotrophic factor family.
Nature. 1990 Mar 22;344(6264):339-41.
PMID: 2314473
- Gibbons TD et al
Fasting for 20 h does not affect exercise-induced increases in circulating
BDNF in humans.
J Physiol. 2023 Jan 11.
PMID: 36631068