neurotensin receptor 3 (sortilin, SORT1)

Function: 1) sorting receptor in the Golgi 2) clearance receptor on the cell surface 3) protein transport from the Golgi apparatus to lysosomes (M6PR-independent) 4) protein transport from Golgi to endosomes 5) promotes neuronal apoptosis by mediating endocytosis of proapoptotic precursor forms of BDNF (proBDNF) & NGFB (proNGFB) 6) receptor for neurotensin 7) scavenges extracellular LPL - mineralization of extracellular matrix during osteogenic differentiation - induced during osteoblast differentiation 8) formation of specialized storage vesicles containing glucose transporter SLC2A4/GLUT4 in adipocytes - vesicles provide a stable pool of SLC2A4 & confer increased responsiveness to insulin 9) transport from endoplasmic reticulum to Golgi (putative) 10) interacts with LPL, SLC2A4, GGA1, GGA2, LRPAP1/RAP, GM2A, PSAP 11) forms complex with NGFR which binds to precursor forms of NGFB (proNGFB) & BDNF (proBDNF) Structure: - N-terminal propeptide may facilitate precursor transport within Golgi - N-terminal propeptide is cleaved by furin - intrachain binding of the N-terminal propeptide & extracellular domain may inhibit premature ligand binding - extracellular domain may be shed following protease cleavage - contains 9 BNR repeats Compartment: - membrane, endoplasmic reticulum, endosomes, Golgi stack, lysosomes, nucleus, plasma membrane (small fraction), SLC2A4/GLUT4 storage vesicles in adipocytes - localization to plasma membrane in adipocytes may be enhanced by insulin Expression: - expressed in brain, spinal cord, heart, skeletal muscle, thyroid, placenta, testis > lymphoid organs, kidney, colon, liver

General

neurotensin receptor phosphoprotein VPS10 domain-containing protein (VPS10)

Properties

SIZE: entity length = 831 aa MW = 92 kD COMPARTMENT: lysosome cell nucleus golgi endoplasmic reticulum MOTIF: signal sequence {1-33} intrachain binding {50-61} cysteine residue {C86} MODIFICATION: cysteine residue {C556} N-glycosylation site {N98} BNR {145-156} N-glycosylation site {N162} BNR {198-209} BNR {240-251} cysteine residue {C257} MODIFICATION: cysteine residue {C277} N-glycosylation site {N274} cysteine residue {C277} MODIFICATION: cysteine residue {C257} BNR {287-298} BNR {328-339} BNR {377-388} N-glycosylation site {N406} BNR {428-439} cysteine residue {C448} MODIFICATION: cysteine residue {C458} cysteine residue {C458} MODIFICATION: cysteine residue {C448} BNR {506-517} BNR {548-559} MOTIF: cysteine residue {C556} MODIFICATION: cysteine residue {C86} N-glycosylation site {N582} LRPAP1/NGFB interaction {612-756} MOTIF: cysteine residue {C612} MODIFICATION: cysteine residue {C651} cysteine residue {C634} MODIFICATION: cysteine residue {C666} cysteine residue {C651} MODIFICATION: cysteine residue {C612} cysteine residue {C666} MODIFICATION: cysteine residue {C634} cysteine residue {C668} MODIFICATION: cysteine residue {C723} cysteine residue {C675} MODIFICATION: cysteine residue {C688} N-glycosylation site {N684} cysteine residue {C688} MODIFICATION: cysteine residue {C675} cysteine residue {C702} MODIFICATION: cysteine residue {C740} cysteine residue {C723} MODIFICATION: cysteine residue {C668} cysteine residue {C740} MODIFICATION: cysteine residue {C702} transmembrane domain {756-778} ER-Golgi transport {779-831} MOTIF: endocytosis signal {787-792} Ser phosphorylation site {S825}

Database Correlations

OMIM 602458 MORBIDMAP 602458 UniProt Q99523 Pfam PF02012 Entrez Gene 6272 Kegg hsa:6272