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neurotensin receptor type 2; NTR2 receptor; NT-R-2; Levocabastine-sensitive neurotensin receptor (NTSR2)
Function:
- receptor for the tridecapeptide neurotensin
- associated with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
neurotensin receptor
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 410 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-32}
transmembrane domain {33-55}
cytoplasmic loop {56-64}
transmembrane domain {65-87}
exoplasmic loop {88-109}
MOTIF: cysteine residue {C108}
MODIFICATION: cysteine residue {C194}
transmembrane domain {110-131}
cytoplasmic loop {132-154}
transmembrane domain {155-176}
exoplasmic loop {177-217}
MOTIF: cysteine residue {C194}
MODIFICATION: cysteine residue {C108}
transmembrane domain {218-237}
cytoplasmic loop {238-297}
transmembrane domain {298-318}
exoplasmic loop {319-337}
transmembrane domain {338-358}
cytoplasmic domain {359-410}
MOTIF: cysteine residue {C377}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 605538
UniProt O95665
Pfam PF00001
Kegg hsa:2362
References
- UniProt :accession O95665
- Wikipedia; Note: neurotensin receptor entry
http://en.wikipedia.org/wiki/neurotensin_receptor