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neurotensin receptor type 1; NT-R-1; high-affinity levocabastine-insensitive neurotensin receptor; NTRH (NTSR1 NTRR)
Function:
- receptor for the tridecapeptide neurotensin
- associated with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Related
neurotensin/neuromedin N; contains: large neuromedin N (NmN-125), neuromedin N (NN, NmN), neurotensin (NT), tail peptide (NTS)
General
neurotensin receptor
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 418 aa
MW = 46 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-63}
MOTIF: N-glycosylation site {N4}
N-glycosylation site {N37}
N-glycosylation site {N41}
transmembrane domain {64-86}
cytoplasmic loop {87-95}
transmembrane domain {96-120}
exoplasmic loop {121-142}
MOTIF: cysteine residue {C141}
MODIFICATION: cysteine residue {C224}
transmembrane domain {143-164}
cytoplasmic loop {165-187}
transmembrane domain {188-209}
exoplasmic loop {210-234}
MOTIF: cysteine residue {C224}
MODIFICATION: cysteine residue {C141}
transmembrane domain {235-259}
cytoplasmic loop {260-303}
transmembrane domain {304-325}
exoplasmic loop {326-343}
transmembrane domain {344-367}
cytoplasmic domain {368-418}
MOTIF: cysteine residue {C383}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 162651
UniProt P30989
Pfam PF00001
Kegg hsa:4923
References
- UniProt :accession P30989
- Wikipedia; Note: neurotensin receptor entry
http://en.wikipedia.org/wiki/neurotensin_receptor
- Tanaka K, Masu M, Nakanishi S.
Structure and functional expression of the cloned rat
neurotensin receptor.
Neuron. 1990 Jun;4(6):847-54.
PMID: 1694443