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neuroserpin; serpin I1; peptidase inhibitor 12; PI-12 (SERPINI1, PI12)
Function:
- serine protease inhibitor
- inhibits plasminogen activators & plasmin but not thrombin
- may be involved in formation or reorganization of synaptic connections as well as in synaptic plasticity in the adult nervous system
- may protect neurons from cell damage by tissue-type plasminogen activator
Structure: belongs to the serpin family
Compartment: secreted
Expression: predominantly expressed in the brain
Pathology:
- defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies
General
glycoprotein
protease inhibitor
secreted protein
Properties
SIZE: entity length = 410 aa
MW = 46 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-16}
N-glycosylation site {N157}
N-glycosylation site {N321}
peptide motif {362-363}
N-glycosylation site {N401}
INHIBITS: protease
Database Correlations
OMIM correlations
MORBIDMAP 602445
UniProt Q99574
Pfam PF00079
Entrez Gene 5274
Kegg hsa:5274
References
- UniProt :accession Q99574
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/SERPINI1