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neuropilin-2; vascular endothelial cell growth factor 165 receptor 2 (NRP2, VEGF165R2)
Function:
- high affinity receptor for semaphorins 3C, 3F, VEGF-165 & VEGF-145 isoforms of VEGF, & the PLGF-2 isoform of PGF
- heterodimer with NRP1 (probable). binds PLXNB1
Structure:
- belongs to the neuropilin family
- contains 2 CUB domains
- contains 2 F5/8 type C domains
- contains 1 MAM domain
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing:
- named isoforms=3; A22, A0, A17
Interactions
molecular events
General
cell surface receptor
glycoprotein
Properties
SIZE: entity length = 931 aa
MW = 105 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
CUB domain {28-142}
MOTIF: cysteine residue {C28}
MODIFICATION: cysteine residue {C55}
cysteine residue {C55}
MODIFICATION: cysteine residue {C28}
cysteine residue {C83}
MODIFICATION: cysteine residue {C105}
cysteine residue {C105}
MODIFICATION: cysteine residue {C83}
CUB domain {149-267}
MOTIF: cysteine residue {C149}
MODIFICATION: cysteine residue {C175}
N-glycosylation site {N152}
N-glycosylation site {N157}
cysteine residue {C175}
MODIFICATION: cysteine residue {C149}
cysteine residue {C208}
MODIFICATION: cysteine residue {C230}
cysteine residue {C230}
MODIFICATION: cysteine residue {C208}
coagulation factors 5/8 type C domain (FA58C) {277-427}
MOTIF: cysteine residue {C277}
MODIFICATION: cysteine residue {C427}
cysteine residue {C427}
MODIFICATION: cysteine residue {C277}
coagulation factors 5/8 type C domain (FA58C) {434-592}
MOTIF: cysteine residue {C434}
MODIFICATION: cysteine residue {C592}
cysteine residue {C592}
MODIFICATION: cysteine residue {C434}
N-glycosylation site {N629}
MAM domain {642-802}
MOTIF: cysteine residue {*1} (2)
MODIFICATION: cysteine residue {*2}
cysteine residue {*2} (2)
MODIFICATION: cysteine residue {*1}
serine-rich region {671-674}
MOTIF: serine residue (SEVERAL)
N-glycosylation site {N839}
transmembrane domain {865-889}
Database Correlations
OMIM 602070
UniProt O60462
PFAM correlations
Entrez Gene 8828
Kegg hsa:8828
References
UniProt :accession O60462
Component-of
molecular complex