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neuropilin & tolloid-like protein 2; brain-specific transmembrane protein containing 2 CUB & 1 LDL-receptor class A domains protein 2 (NETO2, BTCL2, UNQ1926/PRO4401)
Function:
- accessory subunit of neuronal kainate receptors, GRIK2 & GRIK3
- increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, & increasing the open probability of the receptor channels
- modulates the agonist sensitivity of kainate receptors
- slows the decay of kainate receptor-mediated excitatory postsynaptic currents, thus directly influencing synaptic transmission
- interacts with GRIK2 & GRIK3
- does not interact with AMPA receptors or with NMDA receptors
Structure:
- N-glycosylated (putative)
- contains 2 CUB domains
- contains 1 LDL-receptor class A domain
Compartment:
- membrane; single-pass type 1 membrane protein (putative)
Alternative splicing: named isoforms=2
General
glycoprotein
membrane protein
Properties
SIZE: MW = 59 kD
entity length = 525 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-22}
CUB domain {45-159}
MOTIF: cysteine residue {C45}
MODIFICATION: cysteine residue {C72}
cysteine residue {C72}
MODIFICATION: cysteine residue {C45}
cysteine residue {C100}
MODIFICATION: cysteine residue {C122}
cysteine residue {C122}
MODIFICATION: cysteine residue {C100}
CUB domain {177-292}
MOTIF: cysteine residue {C177}
MODIFICATION: cysteine residue {C207}
cysteine residue {C207}
MODIFICATION: cysteine residue {C177}
cysteine residue {C234}
MODIFICATION: cysteine residue {C256}
cysteine residue {C256}
MODIFICATION: cysteine residue {C234}
LDL-receptor class A {296-332}
MOTIF: cysteine residue {C297}
MODIFICATION: cysteine residue {C309}
cysteine residue {C304}
MODIFICATION: cysteine residue {C322}
cysteine residue {C309}
MODIFICATION: cysteine residue {C297}
N-glycosylation site {N311}
cysteine residue {C316}
MODIFICATION: cysteine residue {C331}
cysteine residue {C322}
MODIFICATION: cysteine residue {C304}
cysteine residue {C331}
MODIFICATION: cysteine residue {C316}
transmembrane domain {348-368}
Database Correlations
OMIM 607974
UniProt Q8NC67
PFAM correlations
Entrez Gene 81831
Kegg hsa:81831
References
UniProt :accession Q8NC67