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neuropilin & tolloid-like protein 1; brain-specific transmembrane protein containing 2 CUB & 1 LDL-receptor class A domains protein 1 (NETO1 BTCL1)
Function:
- development &/or maintenance of neuronal circuitry
- accessory subunit of NMDA receptor
- regulates long-term potentiation & cognition, at least in the context of spatial learning & memory
- interacts with PLZ domains of DLG2, DLG3 & DLG4 via its C-terminal TRV domain
- interacts with GRIN2A & GRIN2B via its CUB domains (putative)
Structure:
- contains 2 CUB domains
- contains 1 LDL-receptor class A domain
Compartment:
- isoform 2:
- cell membrane
- cell junction, synapse
- postsynaptic cell membrane, postsynaptic density; component of the postsynaptic density (PSD) of excitatory synapses (putative)
- single-pass type 1 membrane protein (putative)
- isoform 3:
- cell membrane; single-pass type 1 membrane protein
- isoform 1: secreted (putative)
Alternative splicing: named isoforms=3
Expression:
- isoform 1 & isoform 2 are retina-specific
- isoform 3 is found in retina as well as at lower levels in adult & fetal brain
General
glycoprotein
membrane protein
Properties
SIZE: entity length = 533 aa
MW = 60 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-22}
CUB domain {41-155}
MOTIF: cysteine residue {C41}
MODIFICATION: cysteine residue {C68}
cysteine residue {C68}
MODIFICATION: cysteine residue {C41}
cysteine residue {C96}
MODIFICATION: cysteine residue {C118}
cysteine residue {C118}
MODIFICATION: cysteine residue {C96}
CUB domain {172-287}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C202}
cysteine residue {C202}
MODIFICATION: cysteine residue {C172}
cysteine residue {C229}
MODIFICATION: cysteine residue {C251}
cysteine residue {C251}
MODIFICATION: cysteine residue {C229}
LDL-receptor class A {291-327}
MOTIF: cysteine residue {C292}
MODIFICATION: cysteine residue {C304}
cysteine residue {C299}
MODIFICATION: cysteine residue {C317}
cysteine residue {C304}
MODIFICATION: cysteine residue {C292}
N-glycosylation site {N306}
cysteine residue {C311}
MODIFICATION: cysteine residue {C326}
cysteine residue {C317}
MODIFICATION: cysteine residue {C299}
cysteine residue {C326}
MODIFICATION: cysteine residue {C311}
N-glycosylation site {N340}
transmembrane domain {345-365}
Tyr phosphorylation site {Y417}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 531-533
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 607973
UniProt Q8TDF5
PFAM correlations
Entrez Gene 81832
Kegg hsa:81832
References
UniProt :accession Q8TDF5