neuropeptide FF receptor 1; G-protein coupled receptor 147; RFamide-related peptide receptor OT7T022 (NPFFR1, GPR147, NPFF1)

Function: - receptor for NPAF (A-18-F-amide) & NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides - can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands - mediates its action by association with G proteins that activate a phosphatidylinositol-Ca⁺² second messenger system Structure: - belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane; multi-pass membrane protein

General

glycoprotein phosphoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 430 aa MW = 48 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-43} MOTIF: N-glycosylation site {N10} N-glycosylation site {N18} N-glycosylation site {N29} transmembrane domain {44-64} cytoplasmic loop {65-80} transmembrane domain {81-101} exoplasmic loop {102-117} MOTIF: N-glycosylation site {N113} cysteine residue {C116} MODIFICATION: cysteine residue {C203} transmembrane domain {118-138} cytoplasmic loop {139-158} transmembrane domain {159-179} exoplasmic loop {180-214} MOTIF: N-glycosylation site {N195} cysteine residue {C203} MODIFICATION: cysteine residue {C116} transmembrane domain {215-235} MOTIF: Tyr phosphorylation site {Y216} Thr phosphorylation site {T218} Tyr phosphorylation site {Y225} cytoplasmic loop {236-271} transmembrane domain {272-292} exoplasmic loop {293-307} transmembrane domain {308-328} cytoplasmic domain {329-430}

Database Correlations

OMIM 607448 UniProt Q9GZQ6 Pfam PF00001 Entrez Gene 64106 Kegg hsa:64106

References

UniProt :accession Q9GZQ6