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neuron navigator 3 (steerin-3, pore membrane &/or filament-interacting-like protein 1, Unc-53 homolog 3, unc53H3, NAV3, KIAA0938, POMFIL1, STEERIN3)
Function:
1) may regulate IL2 production by T-cells
2) may be involved in neuron regeneration
Structure: contains 1 CH domain (calponin-homology domain)
Compartment: nucleus outer membrane
Alternative splicing: named isoforms=3
Expression:
- highly expressed in brain
- expressed at low levels in heart & placenta
- present in activated T-cells but not in resting T-cells
- expressed in fetal brain
Pathology:
1) down-regulated in primary neuroblastoma
2) defects in NAV3 may be a cause of mycosis fungoides Sezary syndrome
General
nuclear protein
Properties
SIZE: MW = 256 kD
entity length = 2385 aa
COMPARTMENT: cell nucleus
MOTIF: calponin homology domain
NAME: calponin homology domain
SITE: 77-184
glutamine-rich region {618-621}
MOTIF: glutamine residue (SEVERAL)
coiled coil {679-707}
serine-rich region {1032-1560}
MOTIF: serine residue (SEVERAL)
coiled coil {1562-1653}
lysine-rich region {1694-1699}
MOTIF: lysine residue (SEVERAL)
coiled coil {1794-1861}
serine-rich region {1867-1885}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 254400
UniProt Q8IVL0
Pfam PF00307
References
UniProt :accession Q8IVL0