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neuronal PAS domain-containing protein 4 (neuronal PAS4, HLH-PAS transcription factor NXF, NPAS4, NXF)
Function:
1) transcriptional activator in the presence of ARNT
2) activates CME (CNS midline enhancer) element & expression of drebrin gene
3) DNA binding requires dimerization with another bHLH protein
4) forms a heterodimer with ARNT
Structure:
- contains 1 basic helix-loop-helix (bHLH) domain
- contains 1 PAC domain (PAS-associated C-terminal domain)
- contains 2 PAS domains (PER-ARNT-SIM domains)
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: expressed in brain
General
DNA-binding protein
Properties
SIZE: MW = 87 kD
entity length = 802 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 1-13
coiled coil {5-38}
helix-loop-helix
NAME: helix-loop-helix
SITE: 14-54
FOR-BINDING-VIA: helix-loop-helix
PAS domain {70-144}
PAS domain {203-273}
PAC domain {278-317}
coiled coil {624-648}
Database Correlations
OMIM 608554
UniProt Q8IUM7
Pfam PF08447
References
UniProt :accession Q8IUM7