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neuronal PAS domain-containing protein 1 (neuronal PAS1, member of PAS protein 5, basic-helix-loop-helix-PAS protein MOP5, NPAS1, MOP5)
Function:
1) may control regulatory pathways relevant to schizophrenia & to psychosis
2) may play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen
3) efficient DNA binding requires dimerization with another bHLH protein
4) interacts with ARNT
Compartment: nucleus
General
DNA-binding protein
Properties
SIZE: MW = 63 kD
entity length = 590 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 46-58
helix-loop-helix
NAME: helix-loop-helix
SITE: 59-99
FOR-BINDING-VIA: helix-loop-helix
PAS domain {135-207}
serine-rich region {211-222}
MOTIF: serine residue (SEVERAL)
PAS domain {293-359}
PAC domain {365-408}
Database Correlations
OMIM 603346
UniProt Q99742
PFAM correlations
References
UniProt :accession Q99742