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neuronal intranuclear inclusion disease (NIID)
Pathology:
- slowly progressive, neurodegenerative disease
- eosinophilic hyaline intranuclear inclusions in the central nervous system & peripheral nervous system, & in the visceral organs Benetics:
- autosomal dominant
- a CGG repeat expansion in the 5-prime untranslated region of the NOTCH2NLC gene is responsible for neuronal intranuclear inclusion disease
- expansion can be > 100 repeat units in patients
- in healthy individuals 5-43 repeats
Clinical manifestations:
- variable
- include pyramidal symptoms & extrapyramidal symptoms, cerebellar ataxia, cognitive decline & dementia, peripheral neuropathy, & autonomic dysfunction
General
trinucleotide repeat expansion disease
neurodegenerative disease
Database Correlations
OMIM 603472
References
- UniProt :accession P0DPK4