neuronal cell adhesion molecule NRCAM (Nr-CAM, NgCAM-related cell adhesion molecule, Ng-CAM-related, hBravo, NRCAM, KIAA0343)

Function: 1) cell adhesion 2) ankyrin-binding protein involved in neuron-neuron adhesion 3) role in molecular assembly of nodes of Ranvier 4) component of a neurofascin/NRCAM/ankyrin-G complex 5) interacts with GLDN/gliomedin Structure: - belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family - contains 5 fibronectin F3 modules - contains 6 Ig-like C2-type domains (immunoglobulin-like) Compartment: membrane Alternative splicing: named isoforms=5 Expression: - detected in all the examined tissues - in brain, detected in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus & thalamus

General

glycoprotein immunoglobulin superfamily protein neural cell adhesion molecule

Properties

SIZE: MW = 144 kD entity length = 1304 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-24} immunoglobulin superfamily domain {46-134} MOTIF: cysteine residue {C68} MODIFICATION: cysteine residue {C123} N-glycosylation site {N83} cysteine residue {C123} MODIFICATION: cysteine residue {C68} immunoglobulin superfamily domain {141-235} MOTIF: cysteine residue {C167} MODIFICATION: cysteine residue {C218} cysteine residue {C218} MODIFICATION: cysteine residue {C167} N-glycosylation site {N223} N-glycosylation site {N245} N-glycosylation site {N251} immunoglobulin superfamily domain {267-356} MOTIF: N-glycosylation site {N276} cysteine residue {C292} MODIFICATION: cysteine residue {C340} N-glycosylation site {N314} cysteine residue {C340} MODIFICATION: cysteine residue {C292} immunoglobulin superfamily domain {361-448} MOTIF: cysteine residue {C382} MODIFICATION: cysteine residue {C432} cysteine residue {C432} MODIFICATION: cysteine residue {C382} N-glycosylation site {N433} immunoglobulin superfamily domain {454-541} MOTIF: cysteine residue {C476} MODIFICATION: cysteine residue {C525} N-glycosylation site {N507} cysteine residue {C525} MODIFICATION: cysteine residue {C476} immunoglobulin superfamily domain {545-632} MOTIF: cysteine residue {C567} MODIFICATION: cysteine residue {C616} cysteine residue {C616} MODIFICATION: cysteine residue {C567} N-glycosylation site {N619} fibronectin type III domain or F3 module {647-739} MOTIF: N-glycosylation site {N716} fibronectin type III domain or F3 module {746-840} MOTIF: N-glycosylation site {N802} fibronectin type III domain or F3 module {845-947} MOTIF: N-glycosylation site {N858} fibronectin type III domain or F3 module {952-1046} MOTIF: N-glycosylation site {N993} N-glycosylation site {N1009} N-glycosylation site {N1019} fibronectin type III domain or F3 module {1061-1153} MOTIF: N-glycosylation site {N1072} N-glycosylation site {N1083} N-glycosylation site {N1115} transmembrane domain {1168-1190}

Database Correlations

OMIM 601581 UniProt Q92823 PFAM correlations

References

UniProt :accession Q92823