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neuromodulin; axonal membrane protein GAP-43; growth-associated protein 43; PP46; neural phosphoprotein B-50 (GAP43)

Function: - associated with nerve growth - major component of the motile growth cones that form the tips of elongating axons (1% of total growth cone membrane protein) - phosphorylation by a protein kinase C is associated with certain forms of synaptic plasticity - binds calmodulin with a greater affinity in the absence of Ca+2 than in its presence (putative) - inhibits PIP kinase - regulates binding of GTP to Go Structure: - belongs to the neuromodulin family - contains 1 IQ domain Compartment: - cell membrane - peripheral membrane protein cytoplasmic side - cell projection, growth cone membrane - cell junction, synapse - cytoplasmic surface of growth cone & synaptic plasma membranes

Interactions

molecular events

General

calmodulin binding protein PEST protein plasma membrane protein

Properties

SIZE: entity length = 238 aa MW = 25 kD COMPARTMENT: cytoplasm STATE: active state MOTIF: Important for membrane binding {1-4} MOTIF: cysteine residue {C3} MODIFICATION: palmitate COMPARTMENT: membrane cysteine residue {C4} MODIFICATION: palmitate COMPARTMENT: membrane IQ motif {31-60} MOTIF: Ser phosphorylation site {S41} Thr phosphorylation site {T94} Thr phosphorylation site {T181} Ser phosphorylation site {S202} Ser phosphorylation site {S203}

Database Correlations

OMIM 162060 UniProt P17677 PFAM correlations Entrez Gene 2596 Kegg hsa:2596

References

  1. UniProt :accession P17677
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/gap43/
  3. Wikipedia; Gap-43 entry http://en.wikipedia.org/wiki/gap-43_protein
  4. Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: 2556106
  5. Entrez Gene :accession 2596

Component-of

molecular complex