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neuromedin U receptor 2 (G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, NMUR2, TGR1)
Function:
- receptor for the neuromedin U neuropeptide
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in CNS, especially medulla oblongata, pontine reticular formation, spinal cord, thalamus
- expressed in testis > gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen, thymus
Note: uncertain whether Met-1 or Met-4 is the initiato
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 48 kD
entity length = 415 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-49}
MOTIF: N-glycosylation site {N9}
N-glycosylation site {N27}
transmembrane domain {50-70}
cytoplasmic loop {71-82}
transmembrane domain {83-103}
exoplasmic loop {104-123}
MOTIF: cysteine residue {C119}
MODIFICATION: cysteine residue {C204}
transmembrane domain {124-146}
cytoplasmic loop {147-165}
transmembrane domain {166-186}
exoplasmic loop {187-214}
MOTIF: N-glycosylation site {N194}
cysteine residue {C204}
MODIFICATION: cysteine residue {C119}
transmembrane domain {215-235}
cytoplasmic loop {236-265}
transmembrane domain {266-286}
exoplasmic loop {287-301}
transmembrane domain {302-322}
cytoplasmic domain {323-415}
Database Correlations
OMIM 605108
UniProt Q9GZQ4
Pfam PF00001
Kegg hsa:5692
References
UniProt :accession Q9GZQ4