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neuromedin-K receptor; NKR; neurokinin B receptor; NK-3 receptor; NK-3R; tachykinin receptor 3 (TACR3, NK3R, TAC3R)
Function:
- receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B)
- rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P
- associated with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
- anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a Cys
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 465 aa
MW = 52 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-84}
MOTIF: N-glycosylation site {N23}
N-glycosylation site {N50}
N-glycosylation site {N73}
transmembrane domain {85-107}
cytoplasmic loop {108-117}
transmembrane domain {118-139}
exoplasmic loop {140-159}
MOTIF: cysteine residue {C158}
MODIFICATION: cysteine residue {C233}
transmembrane domain {160-181}
cytoplasmic loop {182-201}
transmembrane domain {202-222}
exoplasmic loop {223-245}
MOTIF: cysteine residue {C233}
MODIFICATION: cysteine residue {C158}
transmembrane domain {246-270}
cytoplasmic loop {271-299}
transmembrane domain {300-321}
exoplasmic loop {322-334}
transmembrane domain {335-359}
cytoplasmic domain {360-465}
MOTIF: cysteine residue {C374}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 162332
MORBIDMAP 162332
UniProt P29371
Pfam PF00001
Kegg hsa:6870
References
UniProt :accession P29371