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neurogranin (Ng, NRGN, RC3)
Function:
- brain-specific phosphoprotein
- phosphorylated by protein kinase C
- binds calmodulin in the absence of Ca+2
- regulated by RXR
- regulates calmodulin availability in axons & dendritic spines
- plays a role in long-term potentiation & depression
Structure:
- belongs to the neurogranin family
- contains 1 collagen-like domain
- contains 1 IQ domain
Expression:
- in the cerebral cortex, found in the cell bodies of neurons in layers II-VI, & in apical & basal dendrites of pyramidal neurons
Pathology:
- not found in the dendrites in patients with Alzheimer disease
Laboratory:
- CSF neurogranin is elevated in patients with Alzheimer disease & to a lesser extent mild cognitive impairment [4]
- plasma exosome neurogranin is diminished in patients with Alzheimer disease & mild cognitive impairment [4]
Interactions
molecular events
General
phosphoprotein
Properties
SIZE: MW = 8 kD
entity length = 78 aa
MOTIF: acetylation site
SITE: 1-1
EFFECTOR-BOUND: acetyl
IQ motif {26-47}
MOTIF: Ser phosphorylation site {S36}
FOR-PHOSPHORYLATION-BY: protein kinase C
COLLAGEN-LIKE {48-78}
calmodulin binding site
FOR-BINDING-OF: calmodulin
Database Correlations
OMIM 602350
UniProt Q92686
Pfam PF00612
Entrez Gene 4900
Kegg hsa:4900
References
- OMIM :accession 602350
- Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG,
Tsien JZ, Hu Y.
Effects of environmental enrichment on gene expression in the
brain.
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4.
PMID: 11070096
- UniProt :accession Q92686
- Liu W, Lin H, He X et al
Neurogranin as a cognitive biomarker in cerebrospinal fluid
and blood exosomes for Alzheimer;s disease and mild cognitive
impairment.
Translational Psychiatry April 29, 2020
PMID: 32350238 Free PMC Article
https://www.nature.com/articles/s41398-020-0801-2
Component-of
molecular complex