Search
neurofilament protein
Function:
- neurofilament proteins M & H are highly phosphorylated
Structure:
- neurofilaments usually contain 3 intermediate filament proteins:
a) neurofilament L
b) neurofilament M
c) neurofilament H
- extra mass & high charge density due to tailpiece extensions distinguish neurofilament proteins from all other intermediate filament proteins; this region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions
Interactions
molecular events
Specific
alpha-internexin (alpha-Inx, 66 kD neurofilament protein, neurofilament-66, NF-66, INA)
neurofilament heavy polypeptide; NF-H; neurofilament triplet H protein; 200 kD neurofilament protein (NEFH, KIAA0845, NFH)
neurofilament light polypeptide; NF-L; neurofilament triplet L protein; 68 kD neurofilament protein (NEFL, NF68, NFL)
neurofilament medium polypeptide; NF-M; neurofilament triplet M protein; 160 kD neurofilament protein; neurofilament 3 (NEFM NEF3 NFM)
General
intermediate filament protein
PEST protein
Properties
COMPARTMENT: cytoplasm
CELL: neuron
MOTIF: O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
References
- Cairns NJ, Lee VM, Trojanowski JQ.
The cytoskeleton in neurodegenerative diseases.
J Pathol. 2004 Nov;204(4):438-49. Review.
PMID: 15495240
- UniProt :accession P07196
Component-of
neurofilament