neurofascin (NFASC, KIAA0756)

Function: 1) cell adhesion 2) ankyrin-binding protein 3) neurite extension, axonal guidance, synaptogenesis, myelination & neuron-glial cell interactions (putative) 3) component of a neurofascin/NRCAM/ankyrin-G complex (putative) 4) associates with the sodium channel beta-1 (SCN1B) beta-3 (SCN3B) subunits 5) interacts with GLDN/gliomedin (putative) Structure: 1) belongs to the immunoglobulin superfamily L1/neurofascin/NgCAM family 2) contains 5 fibronectin F3 domains. - contains 6 Ig-like C2-type domains (immunoglobulin-like domains) Compartment: membrane

General

glycoprotein immunoglobulin superfamily protein membrane protein phosphoprotein

Properties

SIZE: MW = 150 kD entity length = 1347 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-24} immunoglobulin superfamily domain {41-137} MOTIF: cysteine residue {C63} MODIFICATION: cysteine residue {C118} cysteine residue {C118} MODIFICATION: cysteine residue {C63} immunoglobulin superfamily domain {143-230} MOTIF: cysteine residue {C162} MODIFICATION: cysteine residue {C213} cysteine residue {C213} MODIFICATION: cysteine residue {C162} immunoglobulin superfamily domain {244-332} MOTIF: cysteine residue {C268} MODIFICATION: cysteine residue {C316} N-glycosylation site {N305} cysteine residue {C316} MODIFICATION: cysteine residue {C268} immunoglobulin superfamily domain {337-424} MOTIF: cysteine residue {C358} MODIFICATION: cysteine residue {C408} cysteine residue {C408} MODIFICATION: cysteine residue {C358} N-glycosylation site {N409} immunoglobulin superfamily domain {429-517} MOTIF: N-glycosylation site {N446} cysteine residue {C452} MODIFICATION: cysteine residue {C501} N-glycosylation site {N483} cysteine residue {C501} MODIFICATION: cysteine residue {C452} immunoglobulin superfamily domain {521-603} MOTIF: cysteine residue {C543} MODIFICATION: cysteine residue {C592} cysteine residue {C592} MODIFICATION: cysteine residue {C543} fibronectin type III domain or F3 module {628-720} fibronectin type III domain or F3 module {727-820} MOTIF: N-glycosylation site {N752} N-glycosylation site {N778} fibronectin type III domain or F3 module {825-927} fibronectin type III domain or F3 module {932-1025} MOTIF: N-glycosylation site {N973} N-glycosylation site {N988} threonine-rich region {1031-1108} MOTIF: threonine residue (SEVERAL) fibronectin type III domain or F3 module {1115-1201} transmembrane domain {1218-1238} Ser phosphorylation site {S1333} Ser phosphorylation site {S1334}

Database Correlations

UniProt O94856 PFAM correlations

References

UniProt :accession O94856