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neuroepithelial cell-transforming gene 1 protein; proto-oncogene p65 Net1; Rho guanine nucleotide exchange factor 8 (NET1, ARHGEF8)
Function:
1) guanine nucleotide exchange factor (GEF) for RhoA GTPase
2) activation of the SAPK/JNK pathway
3) interacts with RHOA in GTP- & GDP-bound states
4) interacts with CDC42 in GTP-bound state
5) interacts with the PDZ 1 domain of BAIAP1
Structure:
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
Compartment: cytoplasm, nucleus
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- induction by TGF-beta
General
rho guanine nucleotide exchange factor
Properties
SIZE: entity length = 596 aa
MW = 68 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: nuclear translocation signal {1-74}
MOTIF: nuclear translocation signal {12-19}
Ser phosphorylation site {S21}
Ser phosphorylation site {S32}
nuclear translocation signal {66-72}
Ser phosphorylation site {S100}
Ser phosphorylation site {S106}
Dbl homology domain {174-356}
PH domain {386-501}
Ser phosphorylation site {S508}
Database Correlations
OMIM 606450
UniProt Q7Z628
PFAM correlations
Entrez Gene 10276
Kegg hsa:10276
References
- UniProt :accession Q7Z628
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/NET1ID41526ch10p15.html