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neuroendocrine convertase-2 (NEC-2, PC-2, KEX2-like endoprotease 2, PCSK2)
Function:
- role in the processing of hormone & other protein precursors at sites comprised of pairs of basic amino acid residues
- release of protein hormones & neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|-bonds
Structure: belongs to the peptidase S8 family, Furin subfamily
Compartment:
- cytoplasmic vesicle, secretory vesicle
- localized in the secretion granules
General
glycoprotein
neuroendocrine convertase; prohormone convertase (NEC)
Properties
SIZE: entity length = 638 aa
MW = 71 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-25}
active site
SITE: 122-415
MOTIF: aspartate residue {D167}
histidine residue {H208}
cysteine residue {C225}
MODIFICATION: cysteine residue {C376}
cysteine residue {C317}
MODIFICATION: cysteine residue {C347}
cysteine residue {C347}
MODIFICATION: cysteine residue {C317}
N-glycosylation site {N375}
cysteine residue {C376}
MODIFICATION: cysteine residue {C225}
serine residue {S384}
cysteine residue {C468}
MODIFICATION: cysteine residue {C494}
cysteine residue {C494}
MODIFICATION: cysteine residue {C468}
N-glycosylation site {N514}
N-glycosylation site {N524}
Database Correlations
OMIM 162151
UniProt P16519
PFAM correlations
Kegg hsa:5126
ENZYME 3.4.21.94
References
- Barr Cell 66:1 1991
- PROSITE :acccesion PS00136
- UniProt :accession P16519