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neurodegenerative disease

Etiology: - psychosocial stress may be associated with increased risk [6] Pathology: - breakdown of the blood brain barrier occurs in many neurodegenerative disorders [4] - Alzheimer disease - Parkinson disease - Huntington disease - amyotrophic lateral sclerosis - multiple sclerosis - HIV-1-associated dementia - chronic traumatic encephalopathy - neurodegenerative diseases appear to progress by spreading via brain connections [5] Genetics: - defect or alteration in the expression of enzymes catalyzing the removal of ubiquitin from ubiquitin-proteins conjugates may be a characteristic of neurodegenerative diseases [3] Laboratory: - CSF markers - CSF beta-amyloid 1-42 - CSF ptau181, CSF total tau - CSF sTREM2 - CSF TNF-alpha

Specific

AIDS dementia complex; AIDS encephalopathy; HIV-associated dementia (HAD) alcohol-associated dementia Alper's disease; progressive sclerosing poliodystrophy Alzheimer's disease (AD) amyotrophic lateral sclerosis (ALS); Lou Gerig's disease amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam argyrophilic grain disease (AgD) cerebellar degeneration Fahr's disease; striopallidodentate calcinosis; idiopathic basal ganglia calcification familial amyotrophy-dementia-parkinsonism familial British dementia (cerebral amyloid angiopathy ITM2B-related type 1, CAA-ITM2B1) familial Danish dementia (cerebral amyloid angiopathy ITM2B-related type 2, CAA-ITM2B2, heredopathia ophthalmo-oto-encephalica) familial progressive subcortical gliosis; familial dementia, Neumann type frontotemporal dementia; frontotemporal lobar degeneration; frontotemporal neurocognitive disorder (FTD, FTLD) hepatolenticular degeneration; Wilson's disease leukoencephalopathy, diffuse hereditary, with spheroids Levine-Critchley syndrome; neuroacanthocytosis; choreoacanthyocytosis limbic-predominant age-related TDP-43 encephalopathy (LATE); limbic-predominant amnestic neurodegenerative syndrome (LANS) McLeod syndrome; McLeod neuroacanthocytosis syndrome mesial temporal sclerosis; hippocampal sclerosis motor neuron disease multiple sclerosis (MS); includes clinically isolated syndrome neurodegeneration with brain iron accumulation neuronal intranuclear inclusion disease (NIID) normal pressure hydrocephalus (NPH) pallidopontonigral degeneration polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), presenile dementia with bone cysts; Nasu-Hakola disease polyglutamine expansion disorder progressive supranuclear palsy; Steele-Richardson-Olszewski syndrome (PSP) subacute combined degeneration of spinal cord; Lichtheim's disease; Putnam-Dana Syndrome synucleinopathy (includes alpha-synucleinopathy) tauopathy transmissible spongiform encephalopathy (prion disease)

General

degenerative disease neurologic disease

Figures/Diagrams

Neurodegenerative disorders listing Neurodegenerative diseases

References

  1. Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: 15495240
  2. Arendt T. Neurodegeneration and plasticity. Int J Dev Neurosci. 2004 Nov;22(7):507-14. Review. PMID: 15465280
  3. UniProt :accession P15374
  4. Sweeney MD, Sagare AP, Zlokovic BV Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nature Reviews Neurology. Jan 29, 2018 PMID: 29377008 https://www.nature.com/articles/nrneurol.2017.188
  5. Brown JA, Deng J, Neuhaus J et al Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy. Neuron. Oct 14, 2019 PMID: 31623919 https://www.cell.com/neuron/fulltext/S0896-6273(19)30743-3
  6. Song H, Sieurin J, Wirdefeldt K et al Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases. JAMA Neurol. Published online March 9, 2020. PMID: 32150226 https://jamanetwork.com/journals/jamaneurology/fullarticle/2762514
  7. Sadlon A, Takousis P, Ankli B et al. Association of chronic pain with biomarkers of neurodegeneration, microglial activation, and inflammation in cerebrospinal fluid and impaired cognitive function. Ann Neurol 2023 Oct 3 PMID: 37787094 Free article. https://onlinelibrary.wiley.com/doi/10.1002/ana.26804