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neuroblast; neuronal stem cell

neuronal cell competent to under mitosis Function: - during development, radial glia & neuronal axons act as physical scaffolds to support neuroblast locomotion - in adults, neuronal migration is glial-independent since radial glia differentiate into astrocytes after birth - in adults, neuroblasts are capable of migrating using blood vessels as a scaffold [1] Compartment: - within the central nervous system, neuroblasts may be found - within the hilus of the dendate gyrus - these neuroblasts generate dentate granule neurons - neurogenesis in the human dentate gyrus ceases by age 13 [3]* - within the subventricular zone - as interneurons within the olfactory bulb - molecular layer of the cerebellum giving rise to GABAergic interneurons in rabbits [2] - granule cell neurogenesis in rabbit cerebellum discontinues prior to puberty [1] * Ref [4] claims human neurogenesis persists throughout aging from age 14-79. 2 problems here: 1) this is the period after which ref [3] claims neurogenesis ceases in the human hippocampus 2) if neurogenesis were to persist throughout aging from age 14-79 & newly formed granule cells were to accumulate under the older granule cells gradually increasing the thickness of the granule layer, volume of the dentate gyrus should increase throughout aging; ref [4] reports no change in dentate gyrus volume from age 14-79

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neural stem cell neuroblastoma neuron

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cell

References

  1. Segarra M, Kirchmaier BC, Acker-Palmer A A Vascular Perspective On Neuronal Migration. Mech Dev. 2015 Jul 17. pii: S0925-4773(15)30005-8 PMID: 26192337
  2. Ponti G, Peretto P, Bonfanti L. Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits. PLoS One. 2008 Jun 4;3(6):e2366. PMID: 18523645
  3. Sorrells SF, Paredes MF, Cebrian-Silla A Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. April 6, 2018. Published Online March 7, 2018 PMID: 29513649 https://www.nature.com/articles/nature25975
  4. Boldrini M, Fulmore CA, Tartt AN et al Human Hippocampal Neurogenesis Persists throughout Aging. Cell Stem Cell. April 5, 2018. 22(4):589 PMID: 29625071 https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(18)30121-8