contactin-associated protein 1; Caspr1; Caspr; neurexin 4; neurexin IV; p190 (CNTNAP1 CASPR NRXN4)

Function: - seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers - seems to demarcate paranodal region of axo-glial junction - in association with contactin may have a role in signaling between axons & myelinating glial cells - interacts with contactin in cis form Structure: - belongs to the neurexin family - contains 2 EGF-like domains - contains 1 F5/8 type C domain - contains 1 fibrinogen C-terminal domain - contains 4 laminin G-like domains Compartment: membrane Expression: - predominantly expressed in brain - weak expression detected in ovary, pancreas, colon, lung, heart, intestine & testis

General

contactin-associated protein neurexin

Properties

SIZE: entity length = 1384 aa MW = 156 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} coagulation factors 5/8 type C domain (FA58C) {25-168} MOTIF: cysteine residue {C25} MODIFICATION: cysteine residue {C168} N-glycosylation site {N120} N-glycosylation site {N128} cysteine residue {C168} MODIFICATION: cysteine residue {C25} Laminin G-like 1 {203-355} MOTIF: N-glycosylation site {N276} cysteine residue {C323} MODIFICATION: cysteine residue {C355} cysteine residue {C355} MODIFICATION: cysteine residue {C323} Laminin G-like 2 {389-538} MOTIF: N-glycosylation site {N420} N-glycosylation site {N499} cysteine residue {C506} MODIFICATION: cysteine residue {C538} N-glycosylation site {N518} cysteine residue {C538} MODIFICATION: cysteine residue {C506} EGF domain {540-577} MOTIF: cysteine residue {C544} MODIFICATION: cysteine residue {C555} cysteine residue {C549} MODIFICATION: cysteine residue {C564} cysteine residue {C555} MODIFICATION: cysteine residue {C544} cysteine residue {C564} MODIFICATION: cysteine residue {C549} cysteine residue {C566} MODIFICATION: cysteine residue {C576} Fibrinogen C-terminal {576-795} MOTIF: cysteine residue {C576} MODIFICATION: cysteine residue {C566} N-glycosylation site {N597} N-glycosylation site {N653} N-glycosylation site {N664} N-glycosylation site {N763} N-glycosylation site {N804} Laminin G-like 3 {813-956} MOTIF: N-glycosylation site {N843} N-glycosylation site {N860} cysteine residue {C930} MODIFICATION: cysteine residue {C957} N-glycosylation site {N948} N-glycosylation site {N956} EGF domain {957-996} MOTIF: cysteine residue {C957} MODIFICATION: cysteine residue {C930} cysteine residue {C961} MODIFICATION: cysteine residue {C974} cysteine residue {C968} MODIFICATION: cysteine residue {C983} cysteine residue {C974} MODIFICATION: cysteine residue {C961} cysteine residue {C983} MODIFICATION: cysteine residue {C968} cysteine residue {C985} MODIFICATION: cysteine residue {C995} cysteine residue {C995} MODIFICATION: cysteine residue {C985} N-glycosylation site {N1078} Laminin G-like 4 {1088-1250} MOTIF: N-glycosylation site {N1147} cysteine residue {C1209} MODIFICATION: cysteine residue {C1250} cysteine residue {C1250} MODIFICATION: cysteine residue {C1209} transmembrane domain {1284-1304} peptide motif {1328-1369} Ser phosphorylation site {S1383}

Database Correlations

OMIM 602346 UniProt P78357 PFAM correlations Entrez Gene 8506 Kegg hsa:8506

References

UniProt :accession P78357