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neurexin
Compartment:
- a family of cell surface proteins
Expression:
- expressed exclusively in the central nervous system
Genetics:
- at least 6 major neurexins are products of 3 genes, with each neurexin gene containing 2 independent promoters [3]
- the neurexins encoded by the longer transcripts are termed alpha-neurexins; beta-neurexins are encoded by the shorter transcripts
Interactions
molecular events
Specific
contactin-associated protein 1; Caspr1; Caspr; neurexin 4; neurexin IV; p190 (CNTNAP1 CASPR NRXN4)
neurexin alpha (alpha latrotoxin receptor, black widow spider venom receptor)
neurexin beta
neurexin-1
neurexin-2
neurexin-3
General
glycoprotein
plasma membrane protein
Properties
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: glycosylation site
membrane region
References
- Ushkaryov YA et al
Neurexins: synaptic cell surface proteins related to the
alpha-latrotoxin receptor and laminin.
Science 257:50 1992
PMID: 1621094
- Hata Y et al
Interaction of synaptotagmin with the cytoplasmic domains of
neurexins.
Neuron 10:307 1993
PMID: 8439414
- Ullrich B et al
Cartography of neurexins: more than 1000 isoforms generated by
alternative splicing and expressed in distinct subsets of
neurons.
Neuron 14:497 1995
PMID: 7695896
Component-of
molecular complex