neuregulin-4; NRG-4 (NRG4)

Function: - low affinity ligand for the ERBB4 tyrosine kinase receptor - concomitantly recruits ERBB1 coreceptor& ERBB2 coreceptor, resulting in ligand-stimulated Tyr phosphorylation & activation of the ERBB receptors - does not bind to the ERBB1 receptor, ERBB2 receptor & ERBB3 receptor (putative) - proteolytic cleavage close to the plasma membrane on the external face leads to the release of soluble growth factor form (putative) - extensive glycosylation precedes the proteolytic cleavage - interacts with ERBB4 (putative) Structure: - the cytoplasmic domain may be involved in the regulation of trafficking & proteolytic processing - regulation of proteolytic processing involves initial intracellular domain dimerization (putative) - ERBB receptor binding is elicited entirely by the EGF-like domain (putative) - belongs to the neuregulin family - contains 1 EGF-like domain Compartment: - pro-neuregulin-4 - plasma membrane - single-pass type 1 membrane protein - does not seem to be active (putative) - neuregulin-4: secreted (putative)

General

glycoprotein neuregulin

Properties

SIZE: entity length = 115 aa MW = 13 kD COMPARTMENT: cellular membrane MOTIF: EGF domain {5-46} MOTIF: cysteine residue {C9} MODIFICATION: cysteine residue {C23} cysteine residue {C17} MODIFICATION: cysteine residue {C34} cysteine residue {C23} MODIFICATION: cysteine residue {C9} cysteine residue {C34} MODIFICATION: cysteine residue {C17} cysteine residue {C36} MODIFICATION: cysteine residue {C45} N-glycosylation site {N39} cysteine residue {C45} MODIFICATION: cysteine residue {C36} transmembrane domain {63-83}

Database Correlations

OMIM 610894 UniProt Q8WWG1 Entrez Gene 145957 Kegg hsa:145957

References

UniProt :accession Q8WWG1