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neural stem cell

Function: - progenitor cells that can differentiate into neurons, astrocytes or oligodendroglia Compartment: - originally isolated from the subventricular zone of the mouse brain - found in the olfactory bulb where they mature into GABAergic granule neurons - found in the dentate gyrus where they mature into granule cells - also see neuroblast Notes: - the role of neural stem cells in treatment of human diseases including stroke, multiple sclerosis, & Parkinson's disease is an area of investigation - at least one of the major problems is how to coerce newly formed neurons to find their natural connectivities that were established in connection with radial arrays during embryogenesis - progenitor cells transplanted into the striatum rather than the substantia nigra of patients with Parkinson's disease establish connectivities throughout the striatum (see investigational treatment of Parkinson's disease) - in adults, neuroblasts are capable of migrating using blood vessels as a scaffold [2]

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neurogenesis

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stem cell

References

  1. Wikipedia: Neural stem cell http://en.wikipedia.org/wiki/Neural_stem_cell
  2. Segarra M, Kirchmaier BC, Acker-Palmer A A Vascular Perspective On Neuronal Migration. Mech Dev. 2015 Jul 17. pii: S0925-4773(15)30005-8 PMID: 26192337