Search
neural retina-specific leucine zipper protein (NRL, D14S46E)
Function:
- transcription factor
- regulates expression of several rod-specific genes, including RHO & PDE6B
- interacts with FIZ1
- interaction represses transactivation (putative)
Structure:
- belongs to the bZIP family
- contains 1 bZIP domain
Compartment: nucleus
Expression: neural retina
Pathology:
- defects in NRL are the cause of retinitis pigmentosa 27
General
basic leucine zipper (bZIP) family protein
Properties
SIZE: entity length = 237 aa
MW = 26 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 159-185
leucine zipper
SITE: 187-208
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 162080
MORBIDMAP 162080
UniProt P54845
PFAM correlations
Kegg hsa:4901
References
- Mutations of the NRL gene;
Note: Retina International's Scientific newsletter
http://www.retina-international.com/sci-news/nrlmut.htm
- UniProt :accession P54845