netrin receptor UNC5D (Unc-5 homolog D, Unc-5 homolog 4, UNC5D, UNC5H4, KIAA1777, UNQ6012/PRO34692)

Function: 1) receptor for netrin 2) involved in axon guidance 3) mediates axon repulsion of neuronal growth cones in developing nervous system 4) association with DCC (cytoplasmic domain) may trigger signaling for axonal repulsion 5) corticospinal tract axon guidance, independent of DCC 6) apoptosis induction when NOT associated with netrin 7) phosphorylated on different cytoplasmic Tyr 8) proteolytic cleavage by caspases during apoptosis does NOT occur associated with netrin ligand. 9) cleavage by caspases is required to induce apoptosis Structure: - belongs to the unc-5 family - contains 1 death domain - contains 1 Ig-like (immunoglobulin-like) domain - contains 1 Ig-like C2-type domain (immunoglobulin-like) - contains 2 TSP type-1 domains - contains 1 ZU5 domain Compartment: membrane Alternative splicing: named isoforms=2

General

glycoprotein phosphoprotein UNC5 homolog protein

Properties

SIZE: MW = 106 kD entity length = 953 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-32} immunoglobulin superfamily domain {54-151} MOTIF: cysteine residue {C75} MODIFICATION: cysteine residue {C134} N-glycosylation site {N117} cysteine residue {C134} MODIFICATION: cysteine residue {C75} immunoglobulin superfamily domain {153-244} MOTIF: cysteine residue {C180} MODIFICATION: cysteine residue {C231} Thr phosphorylation site {T210} N-glycosylation site {N228} cysteine residue {C231} MODIFICATION: cysteine residue {C180} TSP TYPE-1 1 {252-306} MOTIF: cysteine residue {C264} MODIFICATION: cysteine residue {C301} cysteine residue {C268} MODIFICATION: cysteine residue {C305} cysteine residue {C279} MODIFICATION: cysteine residue {C291} cysteine residue {C291} MODIFICATION: cysteine residue {C279} cysteine residue {C301} MODIFICATION: cysteine residue {C264} cysteine residue {C305} MODIFICATION: cysteine residue {C268} TSP TYPE-1 2 {308-360} MOTIF: N-glycosylation site {N353} N-glycosylation site {N376} transmembrane domain {380-400} proteolytic site {416-417} ZU5 {540-645} binding site SITE: 703-721 FOR-BINDING-OF: netrin receptor DCC death domain NAME: death domain SITE: 859-936

Database Correlations

UniProt Q6UXZ4 PFAM correlations Kegg hsa:1379

References

UniProt :accession Q6UXZ4