netrin receptor UNC5C (Unc-5 homolog C, Unc-5 homolog 3, UNC5C, UNC5H3)

Function: 1) receptor for netrin 2) involved in axon guidance 3) mediates axon repulsion of neuronal growth cones in developing nervous system 4) association with DCC (cytoplasmic domain) may trigger signaling for axonal repulsion 5) corticospinal tract axon guidance, independent of DCC 6) apoptosis induction when NOT associated with netrin 7) phosphorylated on different cytoplasmic Tyr 8) phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase (netrin-dependent) 9) proteolytic cleavage by caspases during apoptosis does NOT occur associated with netrin ligand 10) cleavage by caspases is required to induce apoptosis Structure: - belongs to the unc-5 family - contains 1 death domain - contains 1 Ig-like (immunoglobulin-like) domain - contains 1 Ig-like C2-type domain (immunoglobulin-like) - contains 2 TSP type-1 domains - contains 1 ZU5 domain Compartment: membrane Alternative splicing: named isoforms=2 Expression: - expressed in brain, kidney - not expressed in developing or adult lung Pathology: - down-regulated in multiple cancers including a) colorectal cancer b) breast cancer c) ovarian cancer d) uterine cancer e) stomach cancer f) lung cancer g) kidney cancer

General

glycoprotein phosphoprotein UNC5 homolog protein

Properties

SIZE: MW = 103 kD entity length = 931 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-40} immunoglobulin superfamily domain {62-159} MOTIF: cysteine residue {C83} MODIFICATION: cysteine residue {C142} cysteine residue {C142} MODIFICATION: cysteine residue {C83} immunoglobulin superfamily domain {161-256} MOTIF: cysteine residue {C188} MODIFICATION: cysteine residue {C239} N-glycosylation site {N236} cysteine residue {C239} MODIFICATION: cysteine residue {C188} TSP TYPE-1 1 {260-314} MOTIF: cysteine residue {C272} MODIFICATION: cysteine residue {C309} cysteine residue {C276} MODIFICATION: cysteine residue {C313} cysteine residue {C287} MODIFICATION: cysteine residue {C299} cysteine residue {C299} MODIFICATION: cysteine residue {C287} cysteine residue {C309} MODIFICATION: cysteine residue {C272} cysteine residue {C313} MODIFICATION: cysteine residue {C276} TSP TYPE-1 2 {316-368} MOTIF: N-glycosylation site {N361} transmembrane domain {381-401} proteolytic site {415-416} ZU5 {528-634} MOTIF: Tyr phosphorylation site {Y568} binding site SITE: 694-712 FOR-BINDING-OF: netrin receptor DCC death domain NAME: death domain SITE: 850-929

Database Correlations

OMIM 603610 UniProt O95185 PFAM correlations Kegg hsa:8633

References

UniProt :accession O95185