Netrin-4; beta-netrin; hepar-derived netrin-like protein (NTN4)

Function: 1) role in neural, kidney & vascular development 2) may promote neurite elongation Structure: - may form a homodimer - contains 3 laminin EGF-like domains - contains 1 laminin N-terminal domain - contains 1 NTR domain Compartment: - secreted, extracellular matrix, basement membranes Expression: - expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate & fetal spleen

Properties

SIZE: entity length = 628 aa MW = 70 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} Laminin N-terminal {30-261} MOTIF: N-glycosylation site {N56} N-glycosylation site {N163} EGF domain {262-331} MOTIF: cysteine residue {C262} MODIFICATION: cysteine residue {C271} cysteine residue {C264} MODIFICATION: cysteine residue {C293} cysteine residue {C271} MODIFICATION: cysteine residue {C262} cysteine residue {C293} MODIFICATION: cysteine residue {C264} cysteine residue {C295} MODIFICATION: cysteine residue {C304} cysteine residue {C304} MODIFICATION: cysteine residue {C295} cysteine residue {C307} MODIFICATION: cysteine residue {C329} cysteine residue {C329} MODIFICATION: cysteine residue {C307} EGF domain {332-394} MOTIF: cysteine residue {C332} MODIFICATION: cysteine residue {C341} cysteine residue {C334} MODIFICATION: cysteine residue {C359} cysteine residue {C341} MODIFICATION: cysteine residue {C332} N-glycosylation site {N353} cysteine residue {C359} MODIFICATION: cysteine residue {C334} cysteine residue {C362} MODIFICATION: cysteine residue {C371} cysteine residue {C371} MODIFICATION: cysteine residue {C362} cysteine residue {C374} MODIFICATION: cysteine residue {C392} cysteine residue {C392} MODIFICATION: cysteine residue {C374} EGF domain {395-448} MOTIF: cysteine residue {C395} MODIFICATION: cysteine residue {C413} cysteine residue {C397} MODIFICATION: cysteine residue {C420} cysteine residue {C413} MODIFICATION: cysteine residue {C395} cysteine residue {C420} MODIFICATION: cysteine residue {C397} cysteine residue {C422} MODIFICATION: cysteine residue {C431} cysteine residue {C431} MODIFICATION: cysteine residue {C422} cysteine residue {C434} MODIFICATION: cysteine residue {C446} cysteine residue {C446} MODIFICATION: cysteine residue {C434} N-glycosylation site {N483} NTR {506-627} MOTIF: cysteine residue {C506} MODIFICATION: cysteine residue {C576} cysteine residue {C520} MODIFICATION: cysteine residue {C627} cysteine residue {C576} MODIFICATION: cysteine residue {C506} cysteine residue {C627} MODIFICATION: cysteine residue {C520}

Database Correlations

OMIM 610401 UniProt Q9HB63 PFAM correlations Entrez Gene 59277 Kegg hsa:59277

References

UniProt :accession Q9HB63